A series of N-substituted 2-chloro phenothiazine derived chloro compounds (3a-3c) and morpholine based compounds (5a-5c) has been synthesized. The molecular structures of synthesized compounds were confirmed by using various spectral techniques viz., FT-IR, 1H, 13C NMR and mass spectroscopy. The strong stretching vibrational bands in the region 1696- 1670 cm-1 in FT-IR spectral analysis confirms the presence of carbonyl moiety in the synthesized compounds. The presence of signals in the downfield region (4.2-3.5 Hz) of proton NMR of 5a-5c was due to methylene protons which confirm their formation. The antimicrobial investigations were carried out against one gram positive bacterial species such as Bacillus subtilis and three gram negative species Ralstonia solanacearum, Pseudomonas aeruginosa and Esherichia coli. The antifungal activity was tested against Aspergillus flavus, Fusarium and phoma. The biological results obtained suggest that the microbial growth inhibition was higher in the chloro based N-phenothiazine derivatives (3a-3c) than its morpholine derivative (5a-5c).
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